Garcinia kola, often known as Bitter kola, is a flowering plant found mostly in the tropical rain forest region of Central and West Africa. The seeds are edible and consumed for medicinal purposes [50]. In ethnomedicine, Garcinia kola has been used as a purgative, antiparasitic, and antimicrobial agent, throat infection, diarrhea, bronchitis, and as an aphrodisiac [50,51]. Reported pharmacological effects of the seeds include antidiabetic, antiiflammatory, antipyretic, immunomodulatory, antiatherogenic, antimicrobial, and liver disorders. The extracts of the seed, commonly known as “bitter kola” have been used in African herbal medicine for the treatment of illnesses such as laryngitis, liver diseases, cough, hoarseness of voice, and diabetes and its associated complications (Adedara et al., 2014; Akinmoladun et al., 2015) kola is an edible seed, which belongs to a unique group of plants that help organisms to adapt to stress by influencing multiple regulatory systems responsible for stimulus–response coupling such as the immune system and act also as a general anti-infective agent. G. kola, commonly known as bitter kola or male kola, is used in traditional African medicine for the treatment of various infectious diseases, such as hepatitis, infections due to the influenza virus and other viral diseases. 

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